5INF
Structural basis for acyl-CoA carboxylase-mediated assembly of unusual polyketide synthase extender units incorporated into the stambomycin antibiotics
Summary for 5INF
Entry DOI | 10.2210/pdb5inf/pdb |
Related | 5ING 5INI |
Descriptor | Carboxyl transferase, HEXANOYL-COENZYME A (3 entities in total) |
Functional Keywords | polyketide, crotonase, extender-unit, acyl-coa, transferase |
Biological source | Streptomyces ambofaciens ATCC 23877 |
Total number of polymer chains | 6 |
Total formula weight | 349469.52 |
Authors | Valentic, T.R.,Ray, L.,Miyazawa, T.,Withall, D.M.,Song, L.,Osada, H.,Tsai, S.C.,Challis, G.L. (deposition date: 2016-03-07, release date: 2016-12-28, Last modification date: 2023-09-27) |
Primary citation | Ray, L.,Valentic, T.R.,Miyazawa, T.,Withall, D.M.,Song, L.,Milligan, J.C.,Osada, H.,Takahashi, S.,Tsai, S.C.,Challis, G.L. A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7:13609-13609, 2016 Cited by PubMed: 28000660DOI: 10.1038/ncomms13609 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.751 Å) |
Structure validation
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