5IMX
Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
5IMX の概要
エントリーDOI | 10.2210/pdb5imx/pdb |
分子名称 | ALK tyrosine kinase receptor, 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine (3 entities in total) |
機能のキーワード | kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cell membrane ; Single-pass type I membrane protein : Q9UM73 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 37485.51 |
構造登録者 | |
主引用文献 | Zhang, P.,Dong, J.,Zhong, B.,Zhang, D.,Yuan, H.,Jin, C.,Xu, X.,Li, H.,Zhou, Y.,Liang, Z.,Ji, M.,Xu, T.,Song, G.,Zhang, L.,Chen, G.,Meng, X.,Sun, D.,Shih, J.,Zhang, R.,Hou, G.,Wang, C.,Jin, Y.,Yang, Q. Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. Bioorg.Med.Chem.Lett., 26:1910-1918, 2016 Cited by PubMed: 26979157DOI: 10.1016/j.bmcl.2016.03.017 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.12 Å) |
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