Structure of the primary oncogenic mutant Y641N Hs/AcPRC2 in complex with a pyridone inhibitor

Summary for 5IJ8

DescriptorEnhancer of Zeste Homolog 2 (EZH2),Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... (5 entities in total)
Functional Keywordslysine methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceAnolis carolinensis (Green anole)
Cellular locationNucleus  Q15910 O75530 Q15022
Total number of polymer chains6
Total molecular weight275864.01
Gajiwala, K.S.,Brooun, A.,Deng, Y.-L.,Liu, W. (deposition date: 2016-03-01, release date: 2016-05-04, Last modification date: 2017-11-22)
Primary citation
Brooun, A.,Gajiwala, K.S.,Deng, Y.L.,Liu, W.,Bolanos, B.,Bingham, P.,He, Y.A.,Diehl, W.,Grable, N.,Kung, P.P.,Sutton, S.,Maegley, K.A.,Yu, X.,Stewart, A.E.
Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.
Nat Commun, 7:11384-11384, 2016
PubMed: 27122193 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms11384
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25260.6%9.6%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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