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5IIS

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold

Summary for 5IIS
Entry DOI10.2210/pdb5iis/pdb
DescriptorSerine/threonine-protein kinase pim-1, DI(HYDROXYETHYL)ETHER, 3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide, ... (4 entities in total)
Functional Keywordspim1, moloney murine leukemia, pim447, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationIsoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains1
Total formula weight32534.76
Authors
Bellamacina, C.,Bussiere, D.,Burger, M. (deposition date: 2016-03-01, release date: 2016-04-06, Last modification date: 2016-05-04)
Primary citationNishiguchi, G.A.,Burger, M.T.,Han, W.,Lan, J.,Atallah, G.,Tamez, V.,Lindvall, M.,Bellamacina, C.,Garcia, P.,Feucht, P.,Zavorotinskaya, T.,Dai, Y.,Wong, K.
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Bioorg.Med.Chem.Lett., 26:2328-2332, 2016
Cited by
PubMed: 26995528
DOI: 10.1016/j.bmcl.2016.03.037
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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