5IIS
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold
Summary for 5IIS
Entry DOI | 10.2210/pdb5iis/pdb |
Descriptor | Serine/threonine-protein kinase pim-1, DI(HYDROXYETHYL)ETHER, 3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide, ... (4 entities in total) |
Functional Keywords | pim1, moloney murine leukemia, pim447, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 1 |
Total formula weight | 32534.76 |
Authors | Bellamacina, C.,Bussiere, D.,Burger, M. (deposition date: 2016-03-01, release date: 2016-04-06, Last modification date: 2016-05-04) |
Primary citation | Nishiguchi, G.A.,Burger, M.T.,Han, W.,Lan, J.,Atallah, G.,Tamez, V.,Lindvall, M.,Bellamacina, C.,Garcia, P.,Feucht, P.,Zavorotinskaya, T.,Dai, Y.,Wong, K. Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorg.Med.Chem.Lett., 26:2328-2332, 2016 Cited by PubMed: 26995528DOI: 10.1016/j.bmcl.2016.03.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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