5IIS

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl-amide scaffold

5IIS の概要

• エントリーDOI: 10.2210/pdb5iis/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, DI(HYDROXYETHYL)ETHER, 3-amino-N-(2'-amino-6'-methyl[4,4'-bipyridin]-3-yl)-6-(2-fluorophenyl)pyridine-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: pim1, moloney murine leukemia, pim447, kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32534.76

構造登録者

Bellamacina, C.,Bussiere, D.,Burger, M. (登録日: 2016-03-01, 公開日: 2016-04-06, 最終更新日: 2016-05-04)

主引用文献

Nishiguchi, G.A.,Burger, M.T.,Han, W.,Lan, J.,Atallah, G.,Tamez, V.,Lindvall, M.,Bellamacina, C.,Garcia, P.,Feucht, P.,Zavorotinskaya, T.,Dai, Y.,Wong, K.
Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.
Bioorg.Med.Chem.Lett., 26:2328-2332, 2016

PubMed Abstract: The Pim proteins (1, 2 and 3) are serine/threonine kinases that have been found to be upregulated in many hematological malignancies and solid tumors. As a result of overlapping functions among the three isoforms, inhibition of all three Pim kinases has become an attractive strategy for cancer therapy. Herein we describe our efforts in identifying potent pan-PIM inhibitors that are derived from our previously reported pyridyl carboxamide scaffold as part of a medicinal chemistry strategy to address metabolic stability.

PubMed: 26995528
DOI: 10.1016/j.bmcl.2016.03.037

実験手法

X-RAY DIFFRACTION (2.1 Å)