5IID
Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one
Summary for 5IID
| Entry DOI | 10.2210/pdb5iid/pdb |
| Descriptor | Protein polybromo-1, 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one (3 entities in total) |
| Functional Keywords | bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus : Q86U86 |
| Total number of polymer chains | 2 |
| Total formula weight | 29836.47 |
| Authors | Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S. (deposition date: 2016-03-01, release date: 2016-06-29, Last modification date: 2024-01-10) |
| Primary citation | Myrianthopoulos, V.,Gaboriaud-Kolar, N.,Tallant, C.,Hall, M.L.,Grigoriou, S.,Brownlee, P.M.,Fedorov, O.,Rogers, C.,Heidenreich, D.,Wanior, M.,Drosos, N.,Mexia, N.,Savitsky, P.,Bagratuni, T.,Kastritis, E.,Terpos, E.,Filippakopoulos, P.,Muller, S.,Skaltsounis, A.L.,Downs, J.A.,Knapp, S.,Mikros, E. Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis. J.Med.Chem., 59:8787-8803, 2016 Cited by PubMed: 27617704DOI: 10.1021/acs.jmedchem.6b00355 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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