5IID

Crystal Structure of the fifth bromodomain of human polybromo (PB1) in complex with 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one

5IID の概要

• エントリーDOI: 10.2210/pdb5iid/pdb
• 分子名称: Protein polybromo-1, 2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-1-benzopyran-4-one (3 entities in total)
• 機能のキーワード: bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q86U86
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29836.47

構造登録者

Filippakopoulos, P.,Picaud, S.,Felletar, I.,von Delft, F.,Edwards, A.M.,Arrowsmith, C.H.,Bountra, C.,Knapp, S. (登録日: 2016-03-01, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Myrianthopoulos, V.,Gaboriaud-Kolar, N.,Tallant, C.,Hall, M.L.,Grigoriou, S.,Brownlee, P.M.,Fedorov, O.,Rogers, C.,Heidenreich, D.,Wanior, M.,Drosos, N.,Mexia, N.,Savitsky, P.,Bagratuni, T.,Kastritis, E.,Terpos, E.,Filippakopoulos, P.,Muller, S.,Skaltsounis, A.L.,Downs, J.A.,Knapp, S.,Mikros, E.; Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.; J.Med.Chem., 59:8787-8803, 2016; PubMed: 27617704; DOI: 10.1021/acs.jmedchem.6b00355

実験手法

X-RAY DIFFRACTION (2.4 Å)