5IHH

Crystal structure of human transthyretin in complex with luteolin-MeO at 1.35 A resolution

Summary for 5IHH

• Entry DOI: 10.2210/pdb5ihh/pdb
• Related: 4qxv 5en3
• Descriptor: Transthyretin, 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-chromen-4-one, SODIUM ION, ... (4 entities in total)
• Functional Keywords: beta barrel, wild type human ttr, transthyretin, transport protein
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P02766
• Total number of polymer chains: 2
• Total formula weight: 28178.24

Authors

Begum, A.,Nilsson, L.,Olofsson, A.,Sauer-Eriksson, A.E. (deposition date: 2016-02-29, release date: 2016-04-20, Last modification date: 2024-01-10)

• Primary citation: Nilsson, L.,Larsson, A.,Begum, A.,Iakovleva, I.,Carlsson, M.,Brannstrom, K.,Sauer-Eriksson, A.E.,Olofsson, A.; Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity.; Plos One, 11:e0153112-e0153112, 2016; PubMed: 27050398; DOI: 10.1371/journal.pone.0153112

Experimental method

X-RAY DIFFRACTION (1.35 Å)