5IGS

Macrolide 2'-phosphotransferase type I - complex with guanosine and oleandomycin

5IGS の概要

• エントリーDOI: 10.2210/pdb5igs/pdb
• 関連するPDBエントリー: 5IGH 5IGI 5IGJ 5IGP 5IGR 5IGT
• 分子名称: Macrolide 2'-phosphotransferase, ISOPROPYL ALCOHOL, (3S,5R,6S,7R,8R,11R,12S,13R,14S,15S)-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-14-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}-1,9-DIOXASPIRO[2.13]HEXADEC-12-YL 2,6-DIDEOXY-3-O-METHYL-ALPHA-L-ARABINO-HEXOPYRANOSIDE, ... (5 entities in total)
• 機能のキーワード: macrolide phosphotransferase, kinase, transferase-antibiotic complex, transferase/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34298.02

構造登録者

Berghuis, A.M.,Fong, D.H. (登録日: 2016-02-28, 公開日: 2017-04-26, 最終更新日: 2023-09-27)

• 主引用文献: Fong, D.H.,Burk, D.L.,Blanchet, J.,Yan, A.Y.,Berghuis, A.M.; Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance.; Structure, 25:750-761.e5, 2017; PubMed: 28416110; DOI: 10.1016/j.str.2017.03.007

実験手法

X-RAY DIFFRACTION (1.38 Å)