5IF4
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design
Summary for 5IF4
Entry DOI | 10.2210/pdb5if4/pdb |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid (3 entities in total) |
Functional Keywords | myeloid cell leukemia-1, bcl-2, apoptosis, apoptosis-apoptosis inhibitor complex, apoptosis/apoptosis inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 37498.22 |
Authors | Zhao, B. (deposition date: 2016-02-25, release date: 2017-01-18, Last modification date: 2024-03-06) |
Primary citation | Lee, T.,Bian, Z.,Zhao, B.,Hogdal, L.J.,Sensintaffar, J.L.,Goodwin, C.M.,Belmar, J.,Shaw, S.,Tarr, J.C.,Veerasamy, N.,Matulis, S.M.,Koss, B.,Fischer, M.A.,Arnold, A.L.,Camper, D.V.,Browning, C.F.,Rossanese, O.W.,Budhraja, A.,Opferman, J.,Boise, L.H.,Savona, M.R.,Letai, A.,Olejniczak, E.T.,Fesik, S.W. Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. FEBS Lett., 591:240-251, 2017 Cited by PubMed: 27878989DOI: 10.1002/1873-3468.12497 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.392 Å) |
Structure validation
Download full validation report