5IDP

CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone

Summary for 5IDP

• Entry DOI: 10.2210/pdb5idp/pdb
• Descriptor: Cyclin-dependent kinase 8, Cyclin-C, (3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone, ... (5 entities in total)
• Functional Keywords: cdk8 kinase / cyclin c, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P49336 P24863
• Total number of polymer chains: 2
• Total formula weight: 75586.86

Authors

Musil, D.,Blagg, J.,Mallinger, A.,Czodrowski, P.,Schiemann, K. (deposition date: 2016-02-24, release date: 2016-12-21, Last modification date: 2024-01-10)

• Primary citation: Czodrowski, P.,Mallinger, A.,Wienke, D.,Esdar, C.,Poschke, O.,Busch, M.,Rohdich, F.,Eccles, S.A.,Ortiz-Ruiz, M.J.,Schneider, R.,Raynaud, F.I.,Clarke, P.A.,Musil, D.,Schwarz, D.,Dale, T.,Urbahns, K.,Blagg, J.,Schiemann, K.; Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.; J. Med. Chem., 59:9337-9349, 2016; PubMed: 27490956; DOI: 10.1021/acs.jmedchem.6b00597

Experimental method

X-RAY DIFFRACTION (2.65 Å)