5IDP
CDK8-CYCC IN COMPLEX WITH (3-Amino-1H-indazol-5-yl)-[(S)-2-(4-fluoro-phenyl)-piperidin-1-yl]-methanone
Summary for 5IDP
Entry DOI | 10.2210/pdb5idp/pdb |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, (3-amino-1H-indazol-5-yl)[(2S)-2-(4-fluorophenyl)piperidin-1-yl]methanone, ... (5 entities in total) |
Functional Keywords | cdk8 kinase / cyclin c, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P49336 P24863 |
Total number of polymer chains | 2 |
Total formula weight | 75586.86 |
Authors | Musil, D.,Blagg, J.,Mallinger, A.,Czodrowski, P.,Schiemann, K. (deposition date: 2016-02-24, release date: 2016-12-21, Last modification date: 2024-01-10) |
Primary citation | Czodrowski, P.,Mallinger, A.,Wienke, D.,Esdar, C.,Poschke, O.,Busch, M.,Rohdich, F.,Eccles, S.A.,Ortiz-Ruiz, M.J.,Schneider, R.,Raynaud, F.I.,Clarke, P.A.,Musil, D.,Schwarz, D.,Dale, T.,Urbahns, K.,Blagg, J.,Schiemann, K. Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening. J. Med. Chem., 59:9337-9349, 2016 Cited by PubMed: 27490956DOI: 10.1021/acs.jmedchem.6b00597 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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