5IDN

CDK8-CYCC IN COMPLEX WITH [(S)-2-(4-Chloro-phenyl)-pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-methanone

5IDN の概要

• エントリーDOI: 10.2210/pdb5idn/pdb
• 分子名称: Cyclin-dependent kinase 8, Cyclin-C, [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone, ... (6 entities in total)
• 機能のキーワード: cdk8 kinase / cyclin c, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : P49336 P24863
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75582.30

構造登録者

Musil, D.,Blagg, J.,Mallinger, A.,Czodrowski, P.,Schiemann, K. (登録日: 2016-02-24, 公開日: 2016-12-21, 最終更新日: 2024-01-10)

• 主引用文献: Czodrowski, P.,Mallinger, A.,Wienke, D.,Esdar, C.,Poschke, O.,Busch, M.,Rohdich, F.,Eccles, S.A.,Ortiz-Ruiz, M.J.,Schneider, R.,Raynaud, F.I.,Clarke, P.A.,Musil, D.,Schwarz, D.,Dale, T.,Urbahns, K.,Blagg, J.,Schiemann, K.; Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.; J. Med. Chem., 59:9337-9349, 2016; PubMed: 27490956; DOI: 10.1021/acs.jmedchem.6b00597

実験手法

X-RAY DIFFRACTION (2.26 Å)