5ICN

HDAC1:MTA1 in complex with inositol-6-phosphate and a novel peptide inhibitor based on histone H4

5ICN の概要

• エントリーDOI: 10.2210/pdb5icn/pdb
• 分子名称: Metastasis-associated protein MTA1, Histone deacetylase 1, GLY-ALA-6A0-ARG-HIS, ... (6 entities in total)
• 機能のキーワード: transcription repression inositol phosphate corepressor histone deacetylase hdac1 hdac3 histones, transcription, metastasis associated protein, ip6
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 67157.56

構造登録者

Millard, C.J.,Robertson, N.S.,Watson, P.J.,Jameson, A.G.,Schwabe, J.W.R. (登録日: 2016-02-23, 公開日: 2016-05-11, 最終更新日: 2024-01-10)

• 主引用文献: Watson, P.J.,Millard, C.J.,Riley, A.M.,Robertson, N.S.,Wright, L.C.,Godage, H.Y.,Cowley, S.M.,Jamieson, A.G.,Potter, B.V.,Schwabe, J.W.; Insights into the activation mechanism of class I HDAC complexes by inositol phosphates.; Nat Commun, 7:11262-11262, 2016; PubMed: 27109927; DOI: 10.1038/ncomms11262

実験手法

X-RAY DIFFRACTION (3.3 Å)