5ICK

A unique binding model of FXR LBD with feroline

Summary for 5ICK

• Entry DOI: 10.2210/pdb5ick/pdb
• Descriptor: Bile acid receptor, Nuclear receptor coactivator 2, (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate, ... (4 entities in total)
• Functional Keywords: complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1; Nucleus: Q15596
• Total number of polymer chains: 4
• Total formula weight: 57352.09

Authors

Lu, Y.,Li, Y. (deposition date: 2016-02-23, release date: 2017-03-08, Last modification date: 2024-03-20)

• Primary citation: Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y.; A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly; Chembiochem, 18:721-725, 2017; PubMed: 28186695; DOI: 10.1002/cbic.201700059

Experimental method

X-RAY DIFFRACTION (2.47 Å)