5I9N

Crystal structure of B. pseudomallei FabI in complex with NAD and PT412

5I9N の概要

• エントリーDOI: 10.2210/pdb5i9n/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-ethyl-4-fluoro-2-(2-nitrophenoxy)phenol, ... (4 entities in total)
• 機能のキーワード: enoyl-acp reductase, burkholderia pseudomallei, diphenyl ethers, slow-binding inhibitors, oxidoreductase
• 由来する生物種: Burkholderia pseudomallei
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30266.06

構造登録者

Hirschbeck, M.W.,Eltschkner, S.,Tonge, P.J.,Kisker, C. (登録日: 2016-02-20, 公開日: 2017-02-22, 最終更新日: 2024-01-10)

• 主引用文献: Neckles, C.,Eltschkner, S.,Cummings, J.E.,Hirschbeck, M.,Daryaee, F.,Bommineni, G.R.,Zhang, Z.,Spagnuolo, L.,Yu, W.,Davoodi, S.,Slayden, R.A.,Kisker, C.,Tonge, P.J.; Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase.; Biochemistry, 56:1865-1878, 2017; PubMed: 28225601; DOI: 10.1021/acs.biochem.6b01048

実験手法

X-RAY DIFFRACTION (2.512 Å)