5I9M
Crystal structure of B. pseudomallei FabI in complex with NAD and PT408
Summary for 5I9M
Entry DOI | 10.2210/pdb5i9m/pdb |
Descriptor | Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 5-ethyl-4-fluoro-2-[(2-methylpyridin-3-yl)oxy]phenol, ... (4 entities in total) |
Functional Keywords | enoyl-acp reductase, burkholderia pseudomallei, diphenyl ethers, slow-binding inhibitors, oxidoreductase |
Biological source | Burkholderia pseudomallei |
Total number of polymer chains | 3 |
Total formula weight | 90708.24 |
Authors | Hirschbeck, M.W.,Eltschkner, S.,Tonge, P.J.,Kisker, C. (deposition date: 2016-02-20, release date: 2017-02-22, Last modification date: 2024-01-10) |
Primary citation | Neckles, C.,Eltschkner, S.,Cummings, J.E.,Hirschbeck, M.,Daryaee, F.,Bommineni, G.R.,Zhang, Z.,Spagnuolo, L.,Yu, W.,Davoodi, S.,Slayden, R.A.,Kisker, C.,Tonge, P.J. Rationalizing the Binding Kinetics for the Inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP Reductase. Biochemistry, 56:1865-1878, 2017 Cited by PubMed: 28225601DOI: 10.1021/acs.biochem.6b01048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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