5I95

Crystal Structure of Human Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Homodimer bound to NADPH and alpha-Ketoglutaric acid

5I95 の概要

• エントリーDOI: 10.2210/pdb5i95/pdb
• 関連するPDBエントリー: 5I96
• 分子名称: Isocitrate dehydrogenase [NADP], mitochondrial, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ... (7 entities in total)
• 機能のキーワード: idh, icd-m, idp nadp(+)-specific icdh oxalosuccinate decarboxylase, akg, alphakg, oxo-glutarate., oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion: P48735
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49489.87

構造登録者

Zhang, B.,Jin, L.,Wu, W.,Jiang, F.,DeLaBarre, B.,Travins, J.A.,Padyana, A.K. (登録日: 2016-02-19, 公開日: 2017-03-01, 最終更新日: 2023-09-27)

• 主引用文献: Yen, K.,Travins, J.,Wang, F.,David, M.D.,Artin, E.,Straley, K.,Padyana, A.,Gross, S.,DeLaBarre, B.,Tobin, E.,Chen, Y.,Nagaraja, R.,Choe, S.,Jin, L.,Konteatis, Z.,Cianchetta, G.,Saunders, J.O.,Salituro, F.G.,Quivoron, C.,Opolon, P.,Bawa, O.,Saada, V.,Paci, A.,Broutin, S.,Bernard, O.A.,de Botton, S.,Marteyn, B.S.,Pilichowska, M.,Xu, Y.,Fang, C.,Jiang, F.,Wei, W.,Jin, S.,Silverman, L.,Liu, W.,Yang, H.,Dang, L.,Dorsch, M.,Penard-Lacronique, V.,Biller, S.A.,Su, S.M.; AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations.; Cancer Discov, 7:478-493, 2017; PubMed: 28193778; DOI: 10.1158/2159-8290.CD-16-1034

実験手法

X-RAY DIFFRACTION (1.54 Å)