5I7U

Human DPP4 in complex with a novel tricyclic hetero-cycle inhibitor

5I7U の概要

• エントリーDOI: 10.2210/pdb5i7u/pdb
• 分子名称: Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: structure-based drug design, diabetes, dpp4 inhibitors, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 174553.61

構造登録者

Scapin, G. (登録日: 2016-02-18, 公開日: 2016-06-08, 最終更新日: 2023-09-27)

• 主引用文献: Wu, W.L.,Hao, J.,Domalski, M.,Burnett, D.A.,Pissarnitski, D.,Zhao, Z.,Stamford, A.,Scapin, G.,Gao, Y.D.,Soriano, A.,Kelly, T.M.,Yao, Z.,Powles, M.A.,Chen, S.,Mei, H.,Hwa, J.; Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes.; Acs Med.Chem.Lett., 7:498-501, 2016; PubMed: 27190600; DOI: 10.1021/acsmedchemlett.6b00027

実験手法

X-RAY DIFFRACTION (1.95 Å)