5I5K
Structure of complement C5 in complex with eculizumab
Summary for 5I5K
| Entry DOI | 10.2210/pdb5i5k/pdb |
| Descriptor | Complement C5, Eculizumab heavy chain (variable domain), Eculizumab light chain (variable domain), ... (4 entities in total) |
| Functional Keywords | complement, fab, immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 474228.16 |
| Authors | Schatz-Jakobsen, J.A.,Andersen, G.R. (deposition date: 2016-02-15, release date: 2016-03-16, Last modification date: 2024-01-10) |
| Primary citation | Schatz-Jakobsen, J.A.,Zhang, Y.,Johnson, K.,Neill, A.,Sheridan, D.,Andersen, G.R. Structural Basis for Eculizumab-Mediated Inhibition of the Complement Terminal Pathway. J Immunol., 197:337-344, 2016 Cited by PubMed: 27194791DOI: 10.4049/jimmunol.1600280 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (4.2 Å) |
Structure validation
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