5I4V

Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists

5I4V の概要

• エントリーDOI: 10.2210/pdb5i4v/pdb
• 分子名称: Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol, ... (4 entities in total)
• 機能のキーワード: lxrbeta-lbd, rxrbeta-lbd, heterodimer, agonist, dna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: Q15596 Q15596
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118341.54

構造登録者

Chen, G.,McKeever, B.M. (登録日: 2016-02-12, 公開日: 2016-06-29, 最終更新日: 2023-09-27)

• 主引用文献: Zheng, Y.,Zhuang, L.,Fan, K.Y.,Tice, C.M.,Zhao, W.,Dong, C.,Lotesta, S.D.,Leftheris, K.,Lindblom, P.R.,Liu, Z.,Shimada, J.,Noto, P.B.,Meng, S.,Hardy, A.,Howard, L.,Krosky, P.,Guo, J.,Lipinski, K.,Kandpal, G.,Bukhtiyarov, Y.,Zhao, Y.,Lala, D.,Van Orden, R.,Zhou, J.,Chen, G.,Wu, Z.,McKeever, B.M.,McGeehan, G.M.,Gregg, R.E.,Claremon, D.A.,Singh, S.B.; Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist.; J.Med.Chem., 59:3264-3271, 2016; PubMed: 26990539; DOI: 10.1021/acs.jmedchem.5b02029

実験手法

X-RAY DIFFRACTION (2.61 Å)