5I2S

PREFUSION FORM OF THE VESICULAR STOMATITIS VIRUS GLYCOPROTEIN G ECTODOMAIN

「2J6J」から置き換えられました

5I2S の概要

• エントリーDOI: 10.2210/pdb5i2s/pdb
• 分子名称: Glycoprotein G, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: virion protein, membrane protein, envelope protein, membrane fusion, viral protein
• 由来する生物種: Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : P0C2X0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48333.73

構造登録者

Roche, S.,Bressanelli, S. (登録日: 2016-02-09, 公開日: 2016-03-02, 最終更新日: 2024-10-16)

主引用文献

Roche, S.,Rey, F.A.,Gaudin, Y.,Bressanelli, S.
Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G.
Science, 315:843-848, 2007

PubMed Abstract: Glycoprotein G of the vesicular stomatitis virus triggers membrane fusion via a low pH-induced structural rearrangement. Despite the equilibrium between the pre- and postfusion states, the structure of the prefusion form, determined to 3.0 angstrom resolution, shows that the fusogenic transition entails an extensive structural reorganization of G. Comparison with the structure of the postfusion form suggests a pathway for the conformational change. In the prefusion form, G has the shape of a tripod with the fusion loops exposed, which point toward the viral membrane, and with the antigenic sites located at the distal end of the molecule. A large number of G glycoproteins, perhaps organized as in the crystals, act cooperatively to induce membrane merging.

PubMed: 17289996
DOI: 10.1126/SCIENCE.1135710

実験手法

X-RAY DIFFRACTION (3 Å)