5HZE

Mek1 adopts DFG-out conformation when bound to an analog of E6201.

5HZE の概要

• エントリーDOI: 10.2210/pdb5hze/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, (3S,4R,8S,9S,11E)-8,9,16-trihydroxy-3,4-dimethyl-14-(methylamino)-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: mek1, e6201, covalent inhibitor, kinase, mek-1, map2k1, dfg-out, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39360.91

構造登録者

Larsen, N.A.,Bloudoff, K. (登録日: 2016-02-02, 公開日: 2017-05-03)

• 主引用文献: Larsen, N.A.,Bloudoff, K.,Subramanian, V.,Nomoto, K.,Wang, J.; Mek1 adopts DFG-out conformation when bound to an analog of E6201.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)