5HZB

Crystal structure of GII.10 P domain in complex with 2-fucosyllactose (2'FL)

5HZB の概要

• エントリーDOI: 10.2210/pdb5hzb/pdb
• 分子名称: Capsid protein, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: norovirus capsid, p domain, hmo, human milk, 2-fucosyllactose, virus, viral protein
• 由来する生物種: Norovirus GII.10
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69750.03

構造登録者

Hansman, G.S.,Koromyslova, A.D.,Singh, B.K.S. (登録日: 2016-02-02, 公開日: 2016-03-02, 最終更新日: 2024-01-10)

主引用文献

Weichert, S.,Koromyslova, A.,Singh, B.K.,Hansman, S.,Jennewein, S.,Schroten, H.,Hansman, G.S.
Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.
J.Virol., 90:4843-4848, 2016

PubMed Abstract: Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurring decoys in humans.

PubMed: 26889023
DOI: 10.1128/JVI.03223-15

実験手法

X-RAY DIFFRACTION (1.553 Å)