5HVS

Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Biaryltriazole Inhibitor (3i-305)

5HVS の概要

• エントリーDOI: 10.2210/pdb5hvs/pdb
• 関連するPDBエントリー: 5HVT
• 分子名称: Macrophage migration inhibitory factor, SULFATE ION, 3-({2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]quinolin-5-yl}oxy)benzoic acid, ... (5 entities in total)
• 機能のキーワード: cytokine, inhibitor, complex, cytokine-cytokine inhibitor complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 39152.93

構造登録者

Robertson, M.J.,Jorgensen, W.L. (登録日: 2016-01-28, 公開日: 2016-06-29, 最終更新日: 2023-09-27)

• 主引用文献: Cisneros, J.A.,Robertson, M.J.,Valhondo, M.,Jorgensen, W.L.; A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.; J.Am.Chem.Soc., 138:8630-8638, 2016; PubMed: 27299179; DOI: 10.1021/jacs.6b04910

実験手法