5HVB

5-methyl-6-(1-naphthylthio)thieno[2,3-d]pyrimidine 2,4-diamine

Summary for 5HVB

• Entry DOI: 10.2210/pdb5hvb/pdb
• Related: 5HUI
• Descriptor: Dihydrofolate reductase, 5-methyl-6-(naphthalen-1-ylsulfanyl)thieno[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 1
• Total formula weight: 22433.40

Authors

Cody, V. (deposition date: 2016-01-28, release date: 2017-02-01, Last modification date: 2023-09-27)

• Primary citation: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(1-napthylthio)[2,3-d]pyrimidine-2,4-diamines; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)