5HTI

Crystal structure of c-Met kinase domain in complex with LXM108

Summary for 5HTI

• Entry DOI: 10.2210/pdb5hti/pdb
• Descriptor: Hepatocyte growth factor receptor, N-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (3 entities in total)
• Functional Keywords: c-met inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• Total number of polymer chains: 1
• Total formula weight: 36623.18

Authors

Liu, Q.F.,Xu, Y.C. (deposition date: 2016-01-26, release date: 2017-02-01, Last modification date: 2023-11-08)

• Primary citation: Xu, Y.C.,Long, Y.; Crystal structure of c-Met kinase domain in complex with LXM108; to be published,

Experimental method

X-RAY DIFFRACTION (1.66 Å)