5HTB

Crystal structure of haspin (GSG2) in complex with bisubstrate inhibitor ARC-3353

5HTB の概要

• エントリーDOI: 10.2210/pdb5htb/pdb
• 分子名称: Serine/threonine-protein kinase haspin, ARC-3353 inhibitor, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (8 entities in total)
• 機能のキーワード: transferase, kinase, inhibitor, allosteric, structural genomics consortium (sgc), transferase-transferase inhibitor complex, bisubstrate inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q8TF76
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42360.40

構造登録者

Chaikuad, A.,Heroven, C.,Lavogina, D.,Kestav, K.,Uri, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-01-26, 公開日: 2016-05-11, 最終更新日: 2023-04-26)

• 主引用文献: Lavogina, D.,Kestav, K.,Chaikuad, A.,Heroven, C.,Knapp, S.,Uri, A.; Co-crystal structures of the protein kinase haspin with bisubstrate inhibitors.; Acta Crystallogr.,Sect.F, 72:339-345, 2016; PubMed: 27139824; DOI: 10.1107/S2053230X16004611

実験手法

X-RAY DIFFRACTION (1.7 Å)