5HT4

6-substituted pyrrolo[2,3-d]pyrimidine 6-thieno-(4-methoxyphenyl)

5HT4 の概要

• エントリーDOI: 10.2210/pdb5ht4/pdb
• 関連するPDBエントリー: 5HT2
• 分子名称: Dihydrofolate reductase, 7-ethyl-6-[(3-methoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase inhibitor complex with nadph, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : P00374
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22616.49

構造登録者

Cody, V. (登録日: 2016-01-26, 公開日: 2017-02-01, 最終更新日: 2023-09-27)

• 主引用文献: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series of fluorine substituted 5-methyl-6-(4'-methoxyphenythio)[2,3-d]pyrrolo-7-ethyl-2,4-diamines; To Be Published,

実験手法

X-RAY DIFFRACTION (1.6 Å)