5HT0

Crystal structure of an Antibiotic_NAT family aminoglycoside acetyltransferase HMB0038 from an uncultured soil metagenomic sample in complex with coenzyme A

Summary for 5HT0

Entry DOI	10.2210/pdb5ht0/pdb
Descriptor	Aminoglycoside acetyltransferase HMB0005, COENZYME A, SULFATE ION, ... (4 entities in total)
Functional Keywords	antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, coenzyme a, csgid, transferase, center for structural genomics of infectious diseases
Biological source	uncultured bacterium
Total number of polymer chains	6
Total formula weight	179143.42
Authors	Xu, Z.,Stogios, P.J.,Wawrzak, Z.,Skarina, T.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2016-01-26, release date: 2016-03-02, Last modification date: 2023-09-27)
Primary citation	Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A. Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5:263-263, 2022 Cited by PubMed: 35338238 DOI: 10.1038/s42003-022-03219-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.752 Å)

Structure validation