5HT0

Crystal structure of an Antibiotic_NAT family aminoglycoside acetyltransferase HMB0038 from an uncultured soil metagenomic sample in complex with coenzyme A

5HT0 の概要

• エントリーDOI: 10.2210/pdb5ht0/pdb
• 分子名称: Aminoglycoside acetyltransferase HMB0005, COENZYME A, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, metagenome, soil, coenzyme a, csgid, transferase, center for structural genomics of infectious diseases
• 由来する生物種: uncultured bacterium
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 179143.42

構造登録者

Xu, Z.,Stogios, P.J.,Wawrzak, Z.,Skarina, T.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2016-01-26, 公開日: 2016-03-02, 最終更新日: 2023-09-27)

• 主引用文献: Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A.; Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family.; Commun Biol, 5:263-263, 2022; PubMed: 35338238; DOI: 10.1038/s42003-022-03219-w

実験手法

X-RAY DIFFRACTION (2.752 Å)