Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5HRX

Crystal structure of the fifth bromodomain of human PB1 in complex with 1-butylisochromeno[3,4-c]pyrazol-5(2H)-one) compound

Summary for 5HRX
Entry DOI10.2210/pdb5hrx/pdb
DescriptorProtein polybromo-1, 1,2-ETHANEDIOL, 1-butylisochromeno[3,4-c]pyrazol-5(3H)-one, ... (4 entities in total)
Functional Keywordspbrm1, brg1-associated factor 180, transcription, chromatin remodeling
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: Q86U86
Total number of polymer chains2
Total formula weight29904.68
Authors
Tallant, C.,Myrianthopoulos, V.,Gaboriaud-Kolar, N.,Newman, J.A.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Mikros, E.,Knapp, S. (deposition date: 2016-01-24, release date: 2016-10-12, Last modification date: 2024-01-10)
Primary citationMyrianthopoulos, V.,Gaboriaud-Kolar, N.,Tallant, C.,Hall, M.L.,Grigoriou, S.,Brownlee, P.M.,Fedorov, O.,Rogers, C.,Heidenreich, D.,Wanior, M.,Drosos, N.,Mexia, N.,Savitsky, P.,Bagratuni, T.,Kastritis, E.,Terpos, E.,Filippakopoulos, P.,Muller, S.,Skaltsounis, A.L.,Downs, J.A.,Knapp, S.,Mikros, E.
Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.
J.Med.Chem., 59:8787-8803, 2016
Cited by
PubMed: 27617704
DOI: 10.1021/acs.jmedchem.6b00355
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.73 Å)
Structure validation

217705

数据于2024-03-27公开中

PDB statisticsPDBj update infoContact PDBjnumon