5HRV

Crystal structure of the fifth bromodomain of human PB1 in complex with 1-ethylisochromeno[3,4-c]pyrazol-5(2H)-one) compound

5HRV の概要

• エントリーDOI: 10.2210/pdb5hrv/pdb
• 分子名称: Protein polybromo-1, 1-ethylisochromeno[3,4-c]pyrazol-5(3H)-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: brm1, brg1-associated factor 180, transcription, chromatin remodeling
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: Q86U86
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14924.29

構造登録者

Tallant, C.,Myrianthopoulos, V.,Gaboriaud-Kolar, N.,Newman, J.A.,Picaud, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Mikros, E.,Knapp, S. (登録日: 2016-01-24, 公開日: 2016-10-12, 最終更新日: 2024-01-10)

• 主引用文献: Myrianthopoulos, V.,Gaboriaud-Kolar, N.,Tallant, C.,Hall, M.L.,Grigoriou, S.,Brownlee, P.M.,Fedorov, O.,Rogers, C.,Heidenreich, D.,Wanior, M.,Drosos, N.,Mexia, N.,Savitsky, P.,Bagratuni, T.,Kastritis, E.,Terpos, E.,Filippakopoulos, P.,Muller, S.,Skaltsounis, A.L.,Downs, J.A.,Knapp, S.,Mikros, E.; Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.; J.Med.Chem., 59:8787-8803, 2016; PubMed: 27617704; DOI: 10.1021/acs.jmedchem.6b00355

実験手法

X-RAY DIFFRACTION (1.7 Å)