5HRR

HIV Integrase Catalytic Domain containing F185K + A124N + T125S mutations complexed with GSK0002

5HRR の概要

• エントリーDOI: 10.2210/pdb5hrr/pdb
• 関連するPDBエントリー: 5HOT 5HRN 5HRP 5HRS
• 分子名称: Integrase, CACODYLATE ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: viral dna integration, dna binding, ledgf binding, viral protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19127.33

構造登録者

Nolte, R.T. (登録日: 2016-01-24, 公開日: 2016-12-14, 最終更新日: 2024-03-06)

• 主引用文献: Gupta, K.,Turkki, V.,Sherrill-Mix, S.,Hwang, Y.,Eilers, G.,Taylor, L.,McDanal, C.,Wang, P.,Temelkoff, D.,Nolte, R.T.,Velthuisen, E.,Jeffrey, J.,Van Duyne, G.D.,Bushman, F.D.; Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.; PLoS Biol., 14:e1002584-e1002584, 2016; PubMed: 27935939; DOI: 10.1371/journal.pbio.1002584

実験手法

X-RAY DIFFRACTION (1.88 Å)