5HQI
Insulin with proline analog HzP at position B28 in the T2 state
Summary for 5HQI
| Entry DOI | 10.2210/pdb5hqi/pdb |
| Descriptor | Insulin A-Chain, Insulin B-Chain (3 entities in total) |
| Functional Keywords | insulin, non-canonical amino acid, hydroxyproline, non-natural amino acid, unnatural amino acid, hormone |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 5833.65 |
| Authors | Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Tirrell, D.A. (deposition date: 2016-01-21, release date: 2017-01-25, Last modification date: 2023-11-15) |
| Primary citation | Lieblich, S.A.,Fang, K.Y.,Cahn, J.K.B.,Rawson, J.,LeBon, J.,Ku, H.T.,Tirrell, D.A. 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139:8384-8387, 2017 Cited by PubMed: 28598606DOI: 10.1021/jacs.7b00794 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.97 Å) |
Structure validation
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