5HPB

human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine

5HPB の概要

• エントリーDOI: 10.2210/pdb5hpb/pdb
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-methyl-6-{[4-(trifluoromethyl)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total)
• 機能のキーワード: oxidoreductase ternary complex with trifluoromethyl inhibitor, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22643.46

構造登録者

Cody, V.,Ganjee, A. (登録日: 2016-01-20, 公開日: 2017-01-25, 最終更新日: 2023-09-27)

• 主引用文献: Cody, V.,Gangjee, A.; Human dihydrofolate reductase ternary complex with a series offluorine substituted 5-methyl-6-phenythio)thieno[2,3-d]pyrimidine-2,4-diamines; To Be Published,

実験手法

X-RAY DIFFRACTION (1.65 Å)