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5HOA

Crystal structure of c-Met L1195V in complex with SAR125844

5HOA の概要
エントリーDOI10.2210/pdb5hoa/pdb
分子名称Hepatocyte growth factor receptor, 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea (3 entities in total)
機能のキーワードtransferase, inhibitor
由来する生物種Homo sapiens (Human)
細胞内の位置Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
タンパク質・核酸の鎖数1
化学式量合計35843.50
構造登録者
Vallee, F.,Marquette, J.-P. (登録日: 2016-01-19, 公開日: 2016-11-23)
主引用文献Ugolini, A.,Kenigsberg, M.,Rak, A.,Vallee, F.,Houtmann, J.,Lowinski, M.,Capdevila, C.,Khider, J.,Albert, E.,Martinet, N.,Nemecek, C.,Grapinet, S.,Bacque, E.,Roesner, M.,Delaisi, C.,Calvet, L.,Bonche, F.,Semiond, D.,Egile, C.,Goulaouic, H.,Schio, L.
Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).
J.Med.Chem., 59:7066-7074, 2016
Cited by
PubMed: 27355974
DOI: 10.1021/acs.jmedchem.6b00280
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.14 Å)
構造検証レポート
Validation report summary of 5hoa
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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