5HNA

Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH-1251

Summary for 5HNA

Entry DOI	10.2210/pdb5hna/pdb
Related	5HN7 5HN8 5HN9
Descriptor	Farnesyl pyrophosphate synthase, putative, 4-chloro-2-{[3-(decyloxy)-5-hydroxybenzyl]oxy}-5-sulfamoylbenzoic acid (3 entities in total)
Functional Keywords	transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Plasmodium vivax
Total number of polymer chains	4
Total formula weight	177192.88
Authors	Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2016-01-18, release date: 2016-09-07, Last modification date: 2023-09-27)
Primary citation	G Ricci, C.,Liu, Y.L.,Zhang, Y.,Wang, Y.,Zhu, W.,Oldfield, E.,McCammon, J.A. Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry, 55:5180-5190, 2016 Cited by PubMed: 27564465 DOI: 10.1021/acs.biochem.6b00398 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.693 Å)

Structure validation