5HMY

Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 15

5HMY の概要

• エントリーDOI: 10.2210/pdb5hmy/pdb
• 関連するPDBエントリー: 5HMW 5HMX 5HMZ 5HN0
• 分子名称: RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-1,3-phenylene)diacetic acid, ... (4 entities in total)
• 機能のキーワード: inhibitor complex polymerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Dengue virus 3
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74086.04

構造登録者

Noble, C.G. (登録日: 2016-01-17, 公開日: 2016-03-30, 最終更新日: 2023-11-08)

• 主引用文献: Yokokawa, F.,Nilar, S.,Noble, C.G.,Lim, S.P.,Rao, R.,Tania, S.,Wang, G.,Lee, G.,Hunziker, J.,Karuna, R.,Manjunatha, U.,Shi, P.Y.,Smith, P.W.; Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design.; J.Med.Chem., 59:3935-3952, 2016; PubMed: 26984786; DOI: 10.1021/acs.jmedchem.6b00143

実験手法

X-RAY DIFFRACTION (2.1 Å)