5HMX
Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 10
Summary for 5HMX
Entry DOI | 10.2210/pdb5hmx/pdb |
Related | 5HMW 5HMY 5HMZ 5HN0 |
Descriptor | RNA-directed RNA polymerase NS5, ZINC ION, 2,2'-(5-(thiophen-2-yl)-1,3-phenylene)diacetic acid, ... (4 entities in total) |
Functional Keywords | inhibitor complex polymerase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Dengue virus 3 |
Total number of polymer chains | 1 |
Total formula weight | 74308.30 |
Authors | Noble, C.G. (deposition date: 2016-01-17, release date: 2016-03-30, Last modification date: 2023-11-08) |
Primary citation | Yokokawa, F.,Nilar, S.,Noble, C.G.,Lim, S.P.,Rao, R.,Tania, S.,Wang, G.,Lee, G.,Hunziker, J.,Karuna, R.,Manjunatha, U.,Shi, P.Y.,Smith, P.W. Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design J.Med.Chem., 59:3935-3952, 2016 Cited by PubMed: 26984786DOI: 10.1021/acs.jmedchem.6b00143 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report