5HM3

2.25 Angstrom Resolution Crystal Structure of Long-chain-fatty-acid-AMP Ligase FadD32 from Mycobacterium tuberculosis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine

5HM3 の概要

• エントリーDOI: 10.2210/pdb5hm3/pdb
• 分子名称: Long-chain-fatty-acid--AMP ligase FadD32, 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: long-chain-fatty-acid--amp ligase, fadd32, structural genomics, center for structural genomics of infectious diseases, csgid, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 73140.36

構造登録者

Minasov, G.,Warwrzak, Z.,Kuhn, M.L.,Shuvalova, L.,Flores, K.J.,Wilson, D.J.,Grimes, K.D.,Aldrich, C.C.,Anderson, W.A.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2016-01-15, 公開日: 2016-08-03, 最終更新日: 2016-09-07)

• 主引用文献: Kuhn, M.L.,Alexander, E.,Minasov, G.,Page, H.J.,Warwrzak, Z.,Shuvalova, L.,Flores, K.J.,Wilson, D.J.,Shi, C.,Aldrich, C.C.,Anderson, W.F.; Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.; Acs Infect Dis., 2:579-591, 2016; PubMed: 27547819; DOI: 10.1021/acsinfecdis.6b00082

実験手法

X-RAY DIFFRACTION (2.25 Å)