5HKM
DISCOVERY OF NOVEL 7-AZAINDOLES AS PDK1 INHIBITORS
Summary for 5HKM
Entry DOI | 10.2210/pdb5hkm/pdb |
Descriptor | 3-phosphoinositide-dependent protein kinase 1, SULFATE ION, 4-ethyl-6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | pdk1 inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: O15530 |
Total number of polymer chains | 1 |
Total formula weight | 35925.07 |
Authors | Wucherer-Plietker, M.,Esdar, C.,Knoechel, T.,Hillertz, P.,Heinrich, T.,Buchstaller, H.P.,Greiner, H.,Dorsch, D.,Calderini, M.,Bruge, D.,Mueller, T.J.J.,Graedler, U. (deposition date: 2016-01-14, release date: 2016-06-08, Last modification date: 2024-01-10) |
Primary citation | Wucherer-Plietker, M.,Merkul, E.,Muller, T.J.,Esdar, C.,Knochel, T.,Heinrich, T.,Buchstaller, H.P.,Greiner, H.,Dorsch, D.,Finsinger, D.,Calderini, M.,Bruge, D.,Gradler, U. Discovery of novel 7-azaindoles as PDK1 inhibitors. Bioorg.Med.Chem.Lett., 26:3073-3080, 2016 Cited by PubMed: 27217002DOI: 10.1016/j.bmcl.2016.05.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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