5HIJ

Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with betaine

Summary for 5HIJ

• Entry DOI: 10.2210/pdb5hij/pdb
• Related: 5GWX 5H02 5HII 5HIK 5HIL 5HIM
• Descriptor: Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE (3 entities in total)
• Functional Keywords: s-adenosylmethionine-dependent methyltransferases (sam or adomet-mtase), class i, monomethylation of glycine and sarcosine, rate-limiting enzyme in betaine biosynthesis, betaine-mediated feedback inhibition, transferase
• Biological source: Methanohalophilus portucalensis FDF-1
• Total number of polymer chains: 1
• Total formula weight: 32918.44

Authors

Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. (deposition date: 2016-01-12, release date: 2016-11-23, Last modification date: 2023-11-15)

• Primary citation: Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L.; Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity; Sci Rep, 6:38071-38071, 2016; PubMed: 27934872; DOI: 10.1038/srep38071

Experimental method

X-RAY DIFFRACTION (1.93 Å)