5HIJ

Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with betaine

5HIJ の概要

• エントリーDOI: 10.2210/pdb5hij/pdb
• 関連するPDBエントリー: 5GWX 5H02 5HII 5HIK 5HIL 5HIM
• 分子名称: Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE (3 entities in total)
• 機能のキーワード: s-adenosylmethionine-dependent methyltransferases (sam or adomet-mtase), class i, monomethylation of glycine and sarcosine, rate-limiting enzyme in betaine biosynthesis, betaine-mediated feedback inhibition, transferase
• 由来する生物種: Methanohalophilus portucalensis FDF-1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32918.44

構造登録者

Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. (登録日: 2016-01-12, 公開日: 2016-11-23, 最終更新日: 2023-11-15)

• 主引用文献: Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L.; Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity; Sci Rep, 6:38071-38071, 2016; PubMed: 27934872; DOI: 10.1038/srep38071

実験手法

X-RAY DIFFRACTION (1.93 Å)