5HI5
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Summary for 5HI5
Entry DOI | 10.2210/pdb5hi5/pdb |
Related | 5HHV 5HHX 5HI3 5HI4 |
Descriptor | Interleukin-17A, CAT-2000 FAB heavy chain, CAT-2000 light chain, ... (6 entities in total) |
Functional Keywords | il-17a, psoriasis, md simulation, sulfonyl fluoride, inhibitor, macrocycle, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: Q16552 |
Total number of polymer chains | 7 |
Total formula weight | 128874.97 |
Authors | |
Primary citation | Liu, S.,Dakin, L.A.,Xing, L.,Withka, J.M.,Sahasrabudhe, P.V.,Li, W.,Banker, M.E.,Balbo, P.,Shanker, S.,Chrunyk, B.A.,Guo, Z.,Chen, J.M.,Young, J.A.,Bai, G.,Starr, J.T.,Wright, S.W.,Bussenius, J.,Tan, S.,Gopalsamy, A.,Lefker, B.A.,Vincent, F.,Jones, L.H.,Xu, H.,Hoth, L.R.,Geoghegan, K.F.,Qiu, X.,Bunnage, M.E.,Thorarensen, A. Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists. Sci Rep, 6:30859-30859, 2016 Cited by PubMed: 27527709DOI: 10.1038/srep30859 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report