5HH4

Crystal structure of metallo-beta-lactamase IMP-1 in complex with a phosphonate-based inhibitor

5HH4 の概要

• エントリーDOI: 10.2210/pdb5hh4/pdb
• 分子名称: Beta-lactamase IMP-1, ZINC ION, 6-(phosphonomethyl)pyridine-2-carboxylic acid, ... (6 entities in total)
• 機能のキーワード: inhibitor, carbapenamase, pyridine, phosphonate, antibiotic resistance, hydrolase
• 由来する生物種: Serratia marcescens
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102322.22

構造登録者

Hinchliffe, P.,Spencer, J. (登録日: 2016-01-09, 公開日: 2017-01-18, 最終更新日: 2024-01-10)

• 主引用文献: Hinchliffe, P.,Tanner, C.A.,Krismanich, A.P.,Labbe, G.,Goodfellow, V.J.,Marrone, L.,Desoky, A.Y.,Calvopina, K.,Whittle, E.E.,Zeng, F.,Avison, M.B.,Bols, N.C.,Siemann, S.,Spencer, J.,Dmitrienko, G.I.; Structural and Kinetic Studies of the Potent Inhibition of Metallo-beta-lactamases by 6-Phosphonomethylpyridine-2-carboxylates.; Biochemistry, 57:1880-1892, 2018; PubMed: 29485857; DOI: 10.1021/acs.biochem.7b01299

実験手法

X-RAY DIFFRACTION (2 Å)