5HES

Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib

Summary for 5HES

• Entry DOI: 10.2210/pdb5hes/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase MLT, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase, complex, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q9NYL2
• Total number of polymer chains: 2
• Total formula weight: 71568.58

Authors

Mathea, S.,Salah, E.,Abdul Azeez, K.R.,Tallant, C.,Szklarz, M.,Chaikuad, A.,Shrestha, B.,Sorrell, F.J.,Elkins, J.M.,Shrestha, L.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (deposition date: 2016-01-06, release date: 2016-03-30, Last modification date: 2024-01-10)

• Primary citation: Mathea, S.,Abdul Azeez, K.R.,Salah, E.,Tallant, C.,Wolfreys, F.,Konietzny, R.,Fischer, R.,Lou, H.J.,Brennan, P.E.,Schnapp, G.,Pautsch, A.,Kessler, B.M.,Turk, B.E.,Knapp, S.; Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.; Acs Chem.Biol., 11:1595-1602, 2016; PubMed: 26999302; DOI: 10.1021/acschembio.6b00043

Experimental method

X-RAY DIFFRACTION (2.14 Å)