5HES

Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib

5HES の概要

• エントリーDOI: 10.2210/pdb5hes/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase MLT, N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: kinase, complex, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9NYL2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71568.58

構造登録者

Mathea, S.,Salah, E.,Abdul Azeez, K.R.,Tallant, C.,Szklarz, M.,Chaikuad, A.,Shrestha, B.,Sorrell, F.J.,Elkins, J.M.,Shrestha, L.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S. (登録日: 2016-01-06, 公開日: 2016-03-30, 最終更新日: 2024-01-10)

• 主引用文献: Mathea, S.,Abdul Azeez, K.R.,Salah, E.,Tallant, C.,Wolfreys, F.,Konietzny, R.,Fischer, R.,Lou, H.J.,Brennan, P.E.,Schnapp, G.,Pautsch, A.,Kessler, B.M.,Turk, B.E.,Knapp, S.; Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.; Acs Chem.Biol., 11:1595-1602, 2016; PubMed: 26999302; DOI: 10.1021/acschembio.6b00043

実験手法

X-RAY DIFFRACTION (2.14 Å)