5H9R

Crystal Structure of Human Galectin-3 CRD in Complex with TAZTDG

Summary for 5H9R

• Entry DOI: 10.2210/pdb5h9r/pdb
• Related: 4XBN 5H9P 5H9Q 5H9S
• Descriptor: Galectin-3, (2~{S},3~{R},4~{S},5~{R},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol (3 entities in total)
• Functional Keywords: galectin, thio-digalactoside (tdg), pi-arginine interaction, fluorine bonding, sugar binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P17931
• Total number of polymer chains: 1
• Total formula weight: 18375.92

Authors

Hsieh, T.J.,Lin, H.Y.,Lin, C.H. (deposition date: 2015-12-29, release date: 2016-06-29, Last modification date: 2023-11-08)

• Primary citation: Hsieh, T.J.,Lin, H.Y.,Tu, Z.,Lin, T.C.,Wu, S.C.,Tseng, Y.Y.,Liu, F.T.,Danny Hsu, S.T.,Lin, C.H.; Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors; Sci Rep, 6:29457-29457, 2016; PubMed: 27416897; DOI: 10.1038/srep29457

Experimental method

X-RAY DIFFRACTION (1.58 Å)