5H9Q

Crystal Structure of Human Galectin-7 in Complex with TD139

Summary for 5H9Q

Entry DOI	10.2210/pdb5h9q/pdb
Related	4XBQ 5H9P 5H9R 5H9S
Descriptor	Galectin-7, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside (3 entities in total)
Functional Keywords	galectin, thio-digalactoside (td139), pi-arginine interaction, fluorine bonding, sugar binding protein
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P47929
Total number of polymer chains	2
Total formula weight	34923.08
Authors	Hsieh, T.J.,Lin, H.Y.,Lin, C.H. (deposition date: 2015-12-29, release date: 2016-06-29, Last modification date: 2023-11-08)
Primary citation	Hsieh, T.J.,Lin, H.Y.,Tu, Z.,Lin, T.C.,Wu, S.C.,Tseng, Y.Y.,Liu, F.T.,Danny Hsu, S.T.,Lin, C.H. Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors Sci Rep, 6:29457-29457, 2016 Cited by PubMed: 27416897 DOI: 10.1038/srep29457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.931 Å)

Structure validation